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Mechanistic Comparison# Dosing Comparison# Amycretin Dosing# Amycretin dosing is investigational: Subcutaneous: Once-weekly injection, doses up to 60 mg studied in phase 1b/2a over 36 weeks Oral: Daily tablet, doses up to 50 mg (or 2 x 50 mg) studied in phase 1 Phase 2 T2D: Both subcutaneous and oral formulations studied over 36 weeks Phase 3 dose selection will be informed by the completed phase 2 data

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The two major pathways for the degradation of proteins involve the selective elimination through the ubiquitin-proteasome system (UPS) and removal through chaperone-mediated autophagy (CMA) (128)

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They also lack randomized, double-blind, placebo-controlled Phase III clinical trial designs

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