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In order to be very sure of preventing irreversible neurologic damage in vitamin B 12 -deficient individuals, the Food and Nutrition Board of the US National Academy of Medicine advises that all adults limit their intake of folic acid (supplements and fortification) to 1,000 g (1 mg) daily ( Table 3 )

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As a powerful biological antioxidant, Lipoic acid has exhibiting the capability to quench free radicals, and in the body it functions as both a coenzyme, and a necessary component for normal mitochondrial function

By April 2026, they took it out of Category 2 because its nominators withdrew their nominationsbut that doesn't mean it's now clear to use