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The success rate from first-in-human to registration for neuroactive drugs targeting the CNS is significantly lower than for other indications, such as cardiovascular, infectious, inflammatory, and metabolic diseases 3,4

Cancer Sci 97:12601266 Singh A, Misra V, Thimmulappa RK, Lee H, Ames S, Hoque MO, Herman JG, Baylin SB, Sidransky D, Gabrielson E (2006) Dysfunctional KEAP1NRF2 interaction in non-small-cell lung cancer

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