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Free Radic Biol Med (2019) 133:1127

The cytoplasmic [NAD + ]/[NADH] can also be determined by the tissue -ketobutyrate/-hydroxybutyrate, as these metabolites are also substrates of lactate dehydrogenase (Sharma et al., 2021)

As it was previously demonstrated that lysine lactylation was induced by neural excitation, a key molecular mechanism for the development of epilepsy [96], with the detailed results showing the positive association of increase of lysine lactylation and the expression of the immediate-early gene marker of neuronal activity c-Fos [97], it is hypothesized that histone delactylation by HDAC1-3 may inhibit the development of epilepsy and prevent seizures