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While both are synthetic neuropeptides developed in Russia and share a surprising number of similarities, they operate through distinctly different mechanisms and understanding those differences is the key to making sense of the growing body of research surrounding them

produced similar neuroendocrine effects in mice than those caused by an acute fast, including suppression of thyroid and reproductive axes, increased glucocorticoid secretion, increase in hypothalamic AgRP and NPY expression and decreased POMC expression 1, 15

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No consistent serious adverse events have emerged in limited case series