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Its effect is long-term structural repair rather than immediate action-its half-life in rats ranges from several days to nearly two weeks, and the physical formation of synapses also takes several days to weeks to complete

In 1926, Ramn Enrique Gaviola (19001989) developed a first instrument for measuring fluorescence decay in the nanosecond range (Gaviola, 1926), and in the same year, Francis Perrin derived a mathematical relationship between fluorescence lifetime and molecular rotation, thereby contributing to the theoretical understanding of fluorescence lifetime (Perrin, 1926)

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Most patients respond well to a stepped-care approach: physical therapy and medication first, then targeted epidural injections, then minimally invasive options like the MILD procedure or laminectomy if conservative care is not enough