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However, its synthetic derivative has been shown in clinical studies to be of benefit to other organ systems in small doses

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase-1 inhibitor, in healthy volunteers: an integrated phase 1, randomized, double-blind, placebo-controlled, single- and multiple-ascending dose study

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The main drawback of DNP-based SSNMR techniques for protein studies is related to the use of cryogenic temperatures, causing an inhomogeneous line broadening due to the presence of numerous protein conformations at low temperature