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doi: 10.3389/fcimb.2018.00024, 74 LinS.MukherjeeS.LiJ.HouW.PanC.LiuJ

ApoE also appears to be a metal ionophore that can sequester copper and reduce oxidative stress, with ApoE4s antioxidant ability being significantly poorer compared to ApoE3 or ApoE2, presumably due to diminished metal ion binding capacity (Zhang et al., 2022