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The initial strengthening was potentially because nonsmokers were exposed to progressively less CO (and/or other components of secondhand smoke), due to tightened smoking restrictions, while the potential nicotine-associated protection against ANA may have weakened after e-cigarettes became a source

The generated H 2 O 2 is then reduced by GPx enzymes using GSH as a cofactor, resulting in H 2 O and oxidized GSH (GSSG) [71, 72]

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