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One preclinical study (Valdecantos et al., ADA 2024) showed combination benefit in obese rats

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10.3389/fnins.2020.00923 14 HongJ.ChenJ.KanJ.LiuM.YangD

Enzyme Activation Lysyl oxidase, the enzyme responsible for cross-linking collagen and elastin fibers (essential for tissue strength, elasticity, and proper matrix organization), absolutely requires copper as a cofactor - GHK-Cu enhances lysyl oxidase activity by ensuring adequate copper availability, thereby promoting proper collagen and elastin maturation and tissue structural integrity