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Babior BM

PLoS Med 17 , e1003095 (2020)

These prodrugs remain intact and inactive when circulating in plasma, that is, add profragments preferentially cut by enzymes enriched in the tumor (such as histone deacetylase (HDAC) or cathepsin), and then selectively release DON in the target tissue, thereby reducing the dose and increasing the therapeutic index

The composition according to Claim 1, wherein the surfactant is chosen from about 1% to about 40%, based on total polymer weight, of an anionic monomer selected from the group consisting of acrylic acid and methacrylic acid, wherein the average molecular weight of said polymer ranges from about 50,000 to about 10,000,000, as determined by gel permeation chromatography