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This is most marked by the transformation of the hemoglobin present in high concentrations in the RBC cytoplasm to an insoluble product (i.e., Heinz bodies

Neurotoxicology 16:349362 Pope SA, Milton R, Heales SJ (2008) Astrocytes protect against copper-catalysed loss of extracellular glutathione

The reaction works like this: NADPH + GSSG NADP+ + 2GSH

N Engl J Med 386:617628 Beck CE, Trottier ED, Kirby-Allen M, Pastore Y (2022) Acute complications in children with sickle cell disease: prevention and management