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doi: 10.1124/jpet.113.205732 167

The variants of interest include Cys159Ser (C159S), Cys597Ser (U597S), Cys31Ser (C31S), His571Ala (H571A), and Tyr296Ala (Y296A)

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Beyond heavy metals, glutathione conjugates with numerous other toxins including pharmaceutical metabolites, particularly acetaminophen, environmental pollutants such as benzene and volatile organic compounds, pesticide residues, and alcohol metabolites that would otherwise damage cellular structures