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What exists is mechanistic plausibility backed by circadian immunology literature and anecdotal consistency from research protocols that report better inflammatory marker suppression with morning dosing

1 Irrespective of the specific urate-lowering therapy (ULT) selected, fundamental principles entail commencing treatment concurrently with prophylaxis and initiating with a conservative dosage, followed by systematic monitoring of serum uric acid levels and subsequent dose adjustment until the therapeutic target is attained

The formation of TLS was suppressed in the kidneys of sulfasalazine-treated mice on day 21, although still observed (Figure 5, A and B, Supplemental Figure 12)