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This toxicity is characterized by specific microbial alterations and disrupted bile acid metabolism

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In some embodiments, the otic formulation or composition comprises about 1% by weight of the carbomer

The expression levels of immune checkpoint molecules were compared across the risk groups and the results demonstrated that TNF superfamily member (TNFSF)18, CD160, adenosine A2a receptor, neuropilin-1, CD200 and TNFSF9 were markedly upregulated, while CD44 was markedly downregulated in the high-risk group compared with the low-risk group (Fig