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Manavis, R

A phase 3, randomized, controlled trial of resmetirom in NASH with liver fibrosis

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Molecular Identity Full Name Body Protection Compound 157 Structure Pentadecapeptide (15 amino acids) Sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val Molecular Weight ~1419 g/mol Origin Synthetic fragment derived from human gastric juice protein Mechanism of Action Published research identifies several pathways through which BPC-157 may affect tissue: Angiogenesis promotion: Studies show BPC-157 promotes blood vessel formation in animal models (Seiwerth et al., 2018) Nitric oxide system modulation: Interactions with NO pathways have been documented Growth factor activity: Research indicates effects on VEGF and EGF pathways FAK-paxillin pathway: Cell migration studies show activation of focal adhesion kinase Published Research Study Focus Model Publication Seiwerth et al