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Well, new study out of Van Loon's lab has kind of challenged this

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View Study [5]"Mechanism of delta-sleep inducing peptide geroprotective activity" Bondarenko TI, Maboroda EA, Mikhaleva II, 2011 Finding: DSIP showed powerful antioxidant effects in aging rats, activating the body's natural antioxidant defense systems including superoxide dismutase, catalase, and ceruloplasmin

158,159 A randomized, placebo-controlled, double-blind, crossover study assessed the effects of a branded hops dry extract, called Melcalin Hops, on self-reported depression, anxiety, and stress levels in 36 healthy young adults with mild symptoms