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Symptoms of Dyshidrotic Eczema The symptoms typically start suddenly and may include: Itchy or burning sensation before blisters appear Tiny blisters filled with clear fluid Thickening, flaking, or cracking of the skin once blisters dry Pain or sensitivity , especially if skin splits Redness or swelling around the affected area The blisters can last 24 weeks and may leave the skin dry or scaly after healing