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Additional studies using other synthetic analogs of PregS revealed that a negatively charged moiety at the C3 position is, however, essential for positive modulation of NMDARs ( 2+ ([Ca 2+ ]i)-dependent and non-canonical mechanism involving G-proteins (Figure 2)

10.1007/s00204-019-02597-1 46 JasaniB.WeiszD

Discontinuation may be warranted if allergic reactions occur, if side effects persist despite slower dosing, or if baseline conditions (acute kidney injury, active infection) change