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In addition, the multivalent bispecific nanobioconjugated conjugated conjugator mBiNE created by colloidal nanoparticles as substrates can stimulate human epidermal growth factor receptor 2 (HER2)-targeted phagocytosis by simultaneously targeting HER2 and calreticulin-mediated prophagocytosis expressed by cancer cells and generate durable anti-tumor immune responses against HER2-expressing tumors, such as promoting macrophages recruitment and enhancing the phagocytosis of cancer cells by macrophages, promoting higher T cell infiltration and activation, thereby further eliminating cancer cells and improving antitumor efficacy (196)