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In diet-induced obesity (DIO) models, NNMT loss-of-function and selective small-molecule inhibitors reduce white adipose mass and improve metabolic parameters without overt toxicity, positioning NNMT as a tractable target for metabolic-disease research [24]

Biological Activity In animal models, 5-Amino-1MQ markedly reduces body weight and fat mass, improves insulin sensitivity, and reverses diet-induced hepatic steatosis and adiposity 2,3

Ethics declarations Competing interests SJW is the founder of Ridgeline Therapeutics, HN is a paid employee of Ridgeline Therapeutics and, since manuscript submission, ADW has also become a paid employee of Ridgeline Therapeutics

Remember that clinical trials failed to demonstrate statistically significant weight loss in the largest study, leading to development termination in 2007