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Even at recommended doses, acetaminophen can produce a small amount of a toxic byproduct called NAPQI

Pryor WA, In Natural Antioxidants in Human Health and Disease

The abnormal expression of GPx2 was detected in different tumors, and GPx2 was up-regulated in colorectal cancer [51, 52] and down-regulated in prostate intraepithelial neoplasia [53], suggesting that GPx2 plays complex roles in tumorigenesis [23]