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GPx1 (/) mouse fibroblasts showed a decrease in protein kinase B (Akt) phosphorylation at Ser-473 during stimulation with hydrogen peroxide, while GPx1-under-expressed MCF-7 cells did not affect the expression and phosphorylation of p38 MAPK [52]

Graphs plotting and IC 50 , EC 50 , EFFECTMAX calculations were carried out in the bell-shape module (nonlinear regression) of GraphPad Prism v.7.0 (GraphPad Software Inc.) for cell viability assays data

KOREA

272 Moreover, current data indicate that, compared with nonHispanic White older adults, Black and Hispanic older adults are at increased risk for Alzheimer's dementia (see Prevalence section), and underrepresentation may exacerbate disparities by largely ignoring populations who bear the greatest risk