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Studies have indicated that the increase of the autophagy level in vivo can lead to the degradation of ferritin and the increase of iron level, thus leading to oxidative damage of cells through the Fenton reaction [66, 67]

Overall, these results suggest that the use of ALA in liver transplantation is safe as it can be protective against hypoxia and oxidative stress by inducing changes in the gene expressions at the mRNA levels

The proliferation and activation of T cells are associated with a decrease in extracellular GSH levels that subsequently result in a reduction of intracellular GSH levels (87)

Anti-inflammatory properties of N-acetylcysteine on lipopolysaccharide-activated macrophages