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Systemic absorption of topical minoxidil remains minimal, approximately 1.4% of applied dose reaching circulation

3,4 The COX-2 selective drugs are the newer drugs that have recently been made available in the drug market, and some examples include nimesulide, nabumatone, meloxicam, etodolac, celecoxib, and rofecoxib

Whether this translates to human risk is not established, but the medication is contraindicated in anyone with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

Corticosteroids may have direct effects on oxidative stress by decreasing the number and/or activity of cells involved in ROS [110]