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doi:10.1016/S0196-0644(94)70071-0

Heart 99:365372 London G, Covic A, Goldsmith D, Wiecek A, Suleymanlar G, Ortiz A, Massy Z, Lindholm B, Martinez-Castelao A, Fliser D, Agarwal R, Jager KJ, Dekker FW, Blankestijn PJ, Zoccali C (2011) Arterial aging and arterial disease: interplay between central hemodynamics, cardiac work, and organ flow-implications for CKD and cardiovascular disease

5 Integrated mechanisms linking periodontitis, microbiota, and depression Gut dysbiosis is recognized as a significant risk factor for depression, potentially influencing brain function and behavioral expression by altering immune system activation, neurotransmitter synthesis, and the production of metabolic byproducts

In this context , laboratory models allow researchers to analyze how biological systems maintain structural organization, cellular communication, and adaptive balance under controlled conditions