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41 We compared the differences in the HIF regulatory network between healthy proximal tubular cells (PT, n = 13,818) and aPT cells ( n = 2157) in the KPMP reference tissue multiome data

Additionally, alanine is reported to be significantly increased with metformin monotherapy and combined with sulfonylurea, and branched-chain amino acids (valine, leucine, and isoleucine) are increased with metformin therapy (t Hart et al., 2018b)

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