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In healthy tissue, the peptide maintains NO homeostasis by modestly increasing endothelial NOS (eNOS) for beneficial vasodilation while suppressing inducible NOS (iNOS) that drives pathological inflammation

In mice, the peak in glial proliferation is observed during days 2 to 7 days after trauma, and subsequently proliferation gradually subsides

Thus, the design and construction of effective AMPs require an understanding of the mechanisms of known peptides and their effects on the human body