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Moreover, chronic (112) or acute (32) peripheral administration of leptin also stimulates adipose TAG hydrolysis in rats, resulting in a 9- to 16-fold increase in rates of lipolysis

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Some doctors begin with 0.5 IU total per day either once a day or divided into two doses five days a week and they may increase the dose to 1 IU per day after one to two months depending on the patient's status and what the patient's IGF-1 level is