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10 A plot of log BBB permeability (cm/sec) versus log octanol-water partition coefficient shows that increased lipophilicity directly correlates with increased membrane permeability in that the more lipid soluble a molecule is, the more readily it moves from the aqueous environment of blood across the lipid environment of the endothelial cell (EC) membrane and enters the brain

Aguilar-Shea AL, Gallardo-Mayo C, Sanz-Gonzlez R, Paredes I