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Point mutagenesis demonstrates that a major determinant of this differential signalling is a single residue difference in the intracellular juxtamembrane region just C terminal to the NPEY motif of IR and IGF1R (Leu in IR and Phe in IGF1R)

151 However, clinical trials to test its effects in patients have only recently started, and published results of CR interventions are restricted to small pilot studies or case reports, 75, 76, 77, 152, 153, 154, 155, 156, 157, 158, 159 which we summarize in Table 2