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However, although simvastatin alone fails to alter the activity of natural killer T (NKT) cells, CXCL16 overexpression induced by simvastatin recruits and potentiates NKT cells to the liver, and later simvastatin upregulates CD69 and IFN- expression in the NKT cells when SK-Hep1 and NKT cells are co-cultured, and thoroughly activates NKT cells (Yu et al., 2022)