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Yes Neurobion has demonstrated efficacy in reducing the neurological pain component of sciatica and lower back pain, alongside appropriate treatment of the underlying cause

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Its substrate site-targeting mechanism inhibiting NNMT at the nicotinamide binding site provides selectivity over related methyltransferases and other enzymes in the NAD salvage pathway, making it a precise tool compound for studying NNMT-specific enzymatic activity in controlled laboratory systems

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