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This process is marked by chronic low-grade inflammation (inflammaging), diminished adaptive immunity, and a skewed CD4+/CD8+ T cell ratio, leaving older adults more vulnerable to infection, cancer, and poor vaccine responses [47]

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It directly engages NF-kB signaling, the master inflammatory transcription factor governing expression of IL-6, TNF-alpha, IL-1beta, COX-2, and hundreds of related mediators