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BBB penetration remains a primary bottleneck: natural compounds (curcumin, phillyrin A) and some synthetic agents (DFO) exhibit poor brain bioavailability, necessitating delivery system modification (e.g., nanoparticle conjugates) or structural optimization (e.g., vitamin K analogs)

Nourishing Ingredients for Healthier Skin Alongside glutathione, Gluta Max Cream contains skin-conditioning and moisturizing ingredients such as glycerin, aloe vera extract, wheat germ oil, and emollients that help maintain hydration and skin comfort

Statements Author contributions LZ: Data curation, Writing original draft, Writing review & editing

While there are obstacles in reaching targeted tissue delivery and reducing off-target effects, strategies involving nanoparticles and small-molecule inhibitors are actively being investigated [97, 98]