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As a result, further tests and investigations may be conducted to identify various methods of stabilizing such transient backward transitions

Adhesion complex regulators When integrins bind to ECM proteins, the involvement of large protein complexes and signal transduction occur leading to the formation of various evolving complexes, such as primitive adhesions, focal complexes, FAs and fibrillar adhesions [83]

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When used together, they target complementary biological systems cellular energy production and oxidative stress defense which is why many clinicians consider them as part of a combined approach under medical supervision