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Astrocytes also exhibit dysfunctional phenotypes, including impaired potassium and glutamate buffering, which further compromise neuronal health

The first BBB organoids consisted of human endothelial cells, astrocytes, and pericytes, which self-assemble under low-adherence conditions (Urich et al., 2013)

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5) Unlike pramlintide (short-acting amylin, FDA 2005) doesn't require 3-times daily dosing weekly format improves compliance