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An increased liver weight of 110% at one year was not associated with liver tumorigenesis, whereas liver tumorigenicity was seen if the one-year liver weight was 150% of control values (Carmichael et al

Several of the possible molecular targets (genes of histamine-gated chloride channels, pH-gated chloride-channels, pyrantel and levamisole nicotinic acetylcholine receptors (nAChRs), and gamma amino butyric acid (GABA)-gated channels) that have been suggested as molecular targets of ivermectin have not been studied in ectoparasitic organisms

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