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The result is selective apoptosis of FOXO4-high senescent cells, leaving FOXO4-low non-senescent cells intact a selectivity that makes it a uniquely powerful molecular probe for studying the contribution of senescent cell accumulation to tissue dysfunction, ageing phenotypes, and disease biology

If you have or have ever had Leber's hereditary optic neuropathy (slow, painless loss of vision, first in one eye and then in the other eye)

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Preparing mentally for a 4 to 8 week commitment allows patience through the inevitable slow periods and plateaus