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The Nrf2 pathway of SFN is essential for providing the neuroprotective advantages against several brain illnesses through multiple pathways and by activating results in enhanced expression of multiple downstream molecules, i.e., NAD(P)H quinone oxidoreductase-1 (NQO1), Heme oxygenase-1 (HO-1), Glutathione peroxidase-1 (GPx-1), and Gamma-glutamylcysteine synthetase ( -GCS), that provide defense against oxidative stress (95)
PAT enzymes, also known as ZDHHC enzymes, contain the DHHC (Aspartate-Histidine-Histidine-Cysteine) catalytic tetrapeptide and zinc finger domains ( Depalmitoylation modifications are mediated by APT1/2 (LYPLA1/2), palmitoyl protein thioesterases (PPT1/PPT2) and / hydrolase structural domain-containing proteins 17 (ABHD17A/B/C) and ABDH10 ( in vitro ( 3 Emerging roles of palmitoylation in inflammatory signaling pathways 3.1 TLR pathway Toll-like receptors (TLRs) play a crucial role in inflammation and host defense by recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) (56)
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