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PLS is a rare autosomal recessive disease in which DPP1 insufficiency, which is caused by a mutation in the DPP1 gene ( CTSC ), results in diffuse palmoplantar hyperkeratosis, severe prepubertal periodontitis, and premature loss of both deciduous and permanent teeth (46)

The changes in the functional status mitochondria, as well as the changes of mtDNA copy number during oocyte development, will directly affect the quality of oocytes, and their subsequent embryo development [11]

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