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(2004) Proceedings of the National Academy of Sciences (PNAS) , 101(39): 1490714912 Foundational study identifying the EPO/-common receptor heteromer (IRR) as the mediator of EPOs tissue-protective effects, distinct from the EPOR homodimer responsible for erythropoiesis

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This hormonal shift promotes lipolysis, particularly in visceral adipose tissue around the organs, leading to significant reductions in deep abdominal fat with relatively small impact on subcutaneous fat