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Cell lysate (200 g protein) was subjected to immunoprecipitation with antibodies coupled to magnetic beads (Magnosphere MS300/Carboxyl, JSR) or GFP-Trap coupled to magnetic particles (Chromotek)

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Since the skin is removed in a circular manner, it is closer to a scar removal method than a scar regeneration method, so it is sometimes described in papers as a 'scar-free skin removal method.' This is a technology used to remove bone wrinkles, and according to data released by the American Society of Laser Medicine in 2019, it is an effective technology that shows an 85% improvement in wrinkles without scars after just one treatment

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