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Description

It works by fitting directly into the lipid layers of skin to help restore structure and reduce transepidermal water loss (TEWL)

Rapid plasma degradation and limited, variable BBB transport make systemic peripheral dosing of the parent peptide an inefficient route of exposure for any putative central target

Frontiers in pharmacology, 12, 627533

The comparison is therefore partly apples-to-oranges: retatrutide is a finished multi-mechanism molecule, whereas cagrilintides headline performance depends on the partner it is combined with