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The mechanism involves stimulating over 300 different genes associated with tissue repair and remodeling, fibroblast activation and collagen synthesis, epidermal basal stem cell viability, an anti-inflammatory effect, an antioxidant effect and stimulation of microvascular growth

Using the biweight midcorrelation, a similarity matrix was computed from which a signed network was constructed using a soft-thresholding power of 14 (MBH, DVC) or 16 (LPBN), maximising the scale-free topology R2 fit while keeping mean connectivity to a value 100

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