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Prior genetic and postmortem studies have revealed abnormalities in these neurotransmission systems in ASD: genetic studies have revealed altered single-nucleotide polymorphisms (SNPs) in genes related to Glu transporters [6], and postmortem studies have demonstrated the overexpression of mRNA encoding Glu receptors [7]

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Also, two open-label trials using 400 mg/day of riboflavin have decreased migraine attack frequency from 4 attacks per month to 2 attacks per month, and from 8.7 attacks per month to 2.9 attacks per month, respectively (100)

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