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In the United States, the Food and Drug Administration (FDA) classified BPC-157 as Category 2 for compounding due to adverse immune system reactions, peptide-related impurities and insufficient safety information to determine whether it would cause harm when administered to humans

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doi: 10.1038/s41423-021-00661-4 Summary Keywords rheumatoid arthritis, glucose metabolism, lipid metabolism, inflammations, immunity, target of intervention Citation Liang S, Wan L, Wang S, Zhang M, Wang Y, Min W and Zhang Y (2025) Crossing the metabolic homeostasis divide: panoramic decoding of therapeutic targets for metabolic-inflammatory crosstalk in rheumatoid arthritis

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