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B-100 complex can interfere with other medications including but not limited to levodopa, medicines containing oestrogen, hydrazine, certain anti epileptic drugs, phenobaritone, phenytoin, immunosuppressants and some medicines used to treat infections such as isoniazid, pyrazinamide, cycloserne and penicillamine

Conversely, chronic disease states such as hypertension or hyperglycemia generate reactive oxygen species that further exacerbate mitochondrial damage, creating a self-perpetuating cycle