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The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease

Tesamorelin works through growth hormone pathways to target visceral fat specifically, while retatrutide activates GLP-1, GIP, and glucagon receptors to reduce overall body weight and liver fat

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However, significant challenges remain, including the synthesis of stable tripeptides with good tissue penetration, insufficient understanding of their mechanisms of action, the scarcity of studies in larger animal models and human trials, and the lack of direct head-to-head comparisons with larger peptides [75, 95]