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Benefits: Longer duration of action compared to cyanocobalamin May require less frequent dosing Preferred for patients with certain medical conditions Population-Specific Formulation Preferences The choice between cyanocobalamin and hydroxocobalamin depends on individual patient needs

This is because Vitamins B1 and B12 work well together

The association between autoimmune thyroiditis, autoimmune gastritis and type 1 diabetes

Adams, Retention of cyanocobalamin, hydroxocobalamin, and coenzyme B12 after parenteral administration, The Lancet, Volume 292, Issue 7570, 28 September 1968, Pages 710-712, ISSN 0140-6736, Glass GB, Skeggs HR, Lee DH, Jones EL, Hardy WW